CORDIS Project
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This project investigates the function and recruitment mechanisms of the TREX complex, which is crucial for mRNA export from the nucleus to the cytoplasm. By utilizing structural biology and advanced imaging techniques, it aims to clarify how TREX interacts with mRNA and influences gene expression, with implications fo…
Eukaryotic mRNA is transcribed, capped, spliced and poly-adenylated in the nucleus, but translated in the cytoplasm.
Nuclear mRNA export is a key step in gene expression which is still poorly understood in mechanistic detail, but the multi-subunit transcription and export (TREX) complex plays a central role in the process. TREX bridges transcription, RNA processing and packaging to facilitate mRNA export licensing.
Understanding TREX function is relevant to human health, as TREX protects against…
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