CORDIS Project
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This project investigates the structural and functional properties of trimeric autotransporter adhesins (TAAs) in gram-negative bacteria, focusing on the YadA protein from Yersinia enterocolitica. It aims to understand the mechanisms of protein folding and the interaction of TAAs with host tissues, which is critical fo…
Bacterial adhesins play a crucial role in pathogen-host interactions, initiating infections by adhesion to the extracellular matrix and to cell surface proteins prior to invasion. A family of non-fimbrial adhesins, the trimeric autotransporter adhesins (TAAs), has recently been described in gram-negative pathogens.
The common biological role of all these TAAs is to mediate the interaction of pathogenic bacteria with their hosts.
There is an increasing body of evidence that TAAs represent highly…
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