CORDIS Project
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The TRISCPOL project investigates the role of iron-sulphur clusters in human DNA polymerase delta, crucial for DNA replication. By understanding these clusters, the project aims to shed light on genome stability and its implications for cancer and aging.
The human genome is composed of 3 billion base pairs of DNA that are replicated prior to every cell division with an astonishing accuracy.
High-fidelity replication is necessary to maintain genome stability, and hence to avoid premature ageing and cancer.
This project aims at understanding the role of the iron-sulphur (FeS) cluster in human DNA polymerase delta (Pol δ), one of the major replicases.FeS clusters are ancient and versatile co-factors that are commonly known for their function in ele…
UNIVERSITAT ZURICH
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