CORDIS Project
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This project investigates how specific chemical modifications of messenger RNAs, transfer RNAs, and ribosomal RNAs influence protein synthesis in cells. By characterizing RNA modification complexes and their roles in translation, the project aims to uncover mechanisms that could link these modifications to human diseas…
All living cells employ messenger RNAs (mRNA), transfer RNAs (tRNA) and ribosomal RNAs (rRNA) to decode genomic information and synthesize the correct set of proteins at the right sub-cellular localization and at the right time.
The attachment of specific chemical groups to individual RNA bases attributes novel chemical properties and strongly influences their functionality.
In particular, modifications of the tRNA anticodon and critical regions of rRNAs are primed to influence the translation o…
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