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The tRNAtoGO project explores the role of transfer RNA molecules in cancer stem cells, aiming to identify specific tRNA signatures that may predict cancer development. It employs advanced sequencing and genetic techniques to understand how these signatures influence tumor growth.
Cells integrate internal and external stimuli by continuously adapting their transcription and translation. tRNAs are heterogeneous and highly modified molecules necessary to correctly translate mRNAs into proteins.
Even though their discovery goes back to the late 50s, it is only in the last years that their active role in regulating translation has started to be highlighted both in health and disease.
Cancer stem cells (CSC) are a small population of transformed cells able to sustain tumor gro…
UNIVERSITE DE LIEGE
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