CORDIS Project
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This project investigates how malaria parasites manipulate host immune responses through a family of proteins known as rifins. By understanding these interactions, the research aims to reveal the mechanisms of immune evasion and persistence of malaria, potentially leading to new strategies for combating the disease.
Parasites have evolved elaborate strategies that maximise their fitness.
Central to these strategies is their interaction with the host immune system, for instance with immune receptors which mediate pathogen recognition or immune tolerance.
Human malaria parasites encode a family of ~200 rifins, some of which are molecular mimics of human self-identifying proteins and that bind tolerance-inducing receptors.
However, very few host targets of rifin proteins are known.
Our data suggests that the f…
INSTITUT DE RECHERCHE POUR LE DEVELOPPEMENT
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