CORDIS Project
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This project explores a novel cancer immunotherapy by reprogramming tumor cells into antigen-presenting cells using specific transcription factors. The goal is to enhance immune responses against tumors by enabling these reprogrammed cells to present tumor antigens effectively, potentially leading to improved cancer tr…
An important hallmark of cancer is the ability to evade the immune system.
Genetic mutations in tumor cells result in the accumulation of tumor antigens (TAs), however, increased cell heterogeneity, downregulation of antigen presentation or inhibition of immune cell infiltration allows immune surveillance evasion.
For the first time, direct cell reprogramming offers exciting opportunities to overcome these challenges.
My group has recently identified a combination of transcription factors (TFs)…
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