CORDIS Project
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This project aims to uncover the mechanisms of transcription termination in eukaryotic cells, focusing on RNA polymerase II. By analyzing genetic and epigenetic factors, it seeks to understand how chromatin context influences this critical process, which is vital for gene expression and protein production.
Most eukaryotic genes are transcribed by RNA polymerase II (Pol II) in a cycle of initiation, elongation and termination.
Transcription termination, defined as the cessation of RNA synthesis and release of Pol II from its DNA template, depends on a functional poly(A) sequence as well as downstream terminator sequences.
Correct termination is important for the prevention of transcriptional interference, efficient protein production and Pol II recycling.
Further on, aberrant poly(A) usage and alte…
THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD
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