CORDIS Project
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This research focuses on the cyclic-AMP signaling pathway in the Trypanosoma brucei parasite, which causes human disease. By mapping protein interactions and understanding how cAMP levels affect cell division, the project aims to identify potential drug targets for treating infections.
This research project will focus on identifying the components of a remarkably divergent cyclic-AMP signalling cascade in the medically important, pathogenic protozoan Trypanosoma brucei.
It will map an interaction network for this unique cAMP pathway and biochemically characterise the lethal effect on cytokinesis that disruption of the intracellular cAMP concentration has on the human-infective form of the parasite.Recently, cAMP metabolism was validated genetically and pharmacologically as an…
LUDWIG-MAXIMILIANS-UNIVERSITAET MUENCHEN
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