CORDIS Project
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This project explores the migration mechanisms of the Trypanosoma brucei parasite, which causes sleeping sickness. It aims to understand how these parasites navigate through host tissues by studying their unique signaling pathways and the role of cyclic AMP in their movement.
Many protozoan parasites have complex life cycles requiring migration through different organs in their hosts.
The current mind-set is that parasites act as individuals and that tissue specificity is largely dictated by receptor-ligand interactions between pathogen and host surface molecules.
However, parasites are more autonomous and manipulative than we give them credit for. I propose that self-steering, a mechanism by which groups of cells migrate in response to gradients that they create and…
JULIUS-MAXIMILIANS-UNIVERSITAT WURZBURG
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