CORDIS Project
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This project investigates how the enzyme peroxiredoxin 1, released by tumor cells, affects T cell immunity in cancer. It aims to understand the role of reactive oxygen species in immune suppression and explore strategies to enhance cancer immunotherapy by targeting redox dynamics.
Oxidative stress promotes genomic instability and oncogenic signaling in cancer, yet antioxidant therapies have largely failed to improve, and in some cases have worsened cancer outcomes.
This necessitates a better understanding of how redox dynamics shape not only the biology of cancer cells but their interactions with the host, including the immune system.
Reactive oxygen species (ROS) are essential co-factors in T cell activation but whether cancers exploit this vulnerability to suppress T ce…
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