CORDIS Project
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This project focuses on developing multifunctional agents to combat Alzheimer's Disease by regulating metal ions that contribute to oxidative stress. The novel compounds aim to restore metal homeostasis in the brain while providing neuroprotection and reducing inflammation.
Despite enormous research efforts across academia and pharmaceutical industry, all clinical trials over the last decade have failed in finding a treatment for Alzheimer’s Disease (AD) which remains one of the greatest challenges in drug discovery.
Taking consideration all together three prevailing AD hypotheses:
Amyloid Cascade, Metal Ions and Oxidative Stress, researchers conclude that loss of neurons is due to a high level of oxidative stress produced by nonregulated redox active metal ions su…
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