CORDIS Project
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This project explores the role of common fragile sites in DNA, particularly their impact on genomic instability and cancer development. It aims to understand how these sites contribute to tumor suppressor gene functions and their involvement in diseases like type-2 diabetes.
Common fragile sites (CFSs) are large chromosomal regions identified by conventional cytogenetics as sequences prone to breakage in cells subjected to replication stress.
The interest in CFSs stems from their key role in DNA damage, resulting in chromosomal rearrangements.
The instability of CFSs was correlated with genome instability in precancerous lesions and during tumour progression.
Two opposing views dominate the discussion regarding the role of CFSs.
One school of thought suggested that…
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