CORDIS Project
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The project investigates the co-evolution of transposable elements and Piwi-interacting RNAs in cichlid fish from Lake Malawi, focusing on their roles in fertility, brain development, and genetic conflicts. It aims to explore how these genetic interactions contribute to the rapid diversification of cichlid species.
Proper regulation of transposable elements (TEs) by Piwi-interacting RNAs (piRNAs) is critical for fertility and embryogenesis in animals.
Because TEs need to evade silencing to replicate, they are engaged in an evolutionary arms race-type of genetic conflict with their host.
These arms races between TEs and the piRNA pathway result in rapid evolution of piRNAs and piRNA regulatory factors, which in turn leads to genetic incompatibilities observable in interspecific hybrids that are relevant to…
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