CORDIS Project
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This project aims to study the sodium leak channel's regulation and develop designer proteins to modulate its function, which is crucial for cell excitability. The research seeks to uncover the channel's physiology and potential therapeutic strategies.
The sodium leak channel (NALCN) is the ion-channel subunit of the NALCN channelosome, additionally containing UNC79, UNC80 and Fam155. NALCN controls the resting membrane potential (RMP) in excitable tissue (e.g. brain and myometrium) by an inward current of positively charged (sodium) ions that depolarizes the cell membrane, sensitizing the cell to excite (activate). NALCN is essential for survival.
Mutations in the NALCN channelosome cause loss- or gain of function of NALCN currents which resu…
KOBENHAVNS UNIVERSITET
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