CORDIS Project
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This project investigates how kinesin-1, a motor protein, transports materials within neurons by examining its interaction with microtubules. Using advanced imaging techniques, it aims to understand the mechanisms controlling kinesin-1 localization and its implications for neuronal transport and related diseases.
Kinesin-1 transports cellular cargos along microtubules as part of neuronal transport.
The localisation of kinesin-1 in neurons is tightly controlled to ensure the coordinated delivery of specific cargoes to the regions where they are required.
One mechanism of control is through microtubule regulation, but the details of this are not well understood.
It has recently been shown that microtubule lattice spacing influences kinesin-1 localisation in U2OS cells.
However, the role lattice spacing pla…
UNIVERSITEIT UTRECHT
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