CORDIS Project
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This project investigates the role of the phosphoinositide 3-kinase delta isoform in T cell activation within lymph nodes. Using advanced imaging techniques, it aims to understand how this pathway influences immune responses and its implications for autoimmune diseases.
The adaptive immune system protects us from nocuous microbes, yet excessive immune reactions can lead to the development of autoimmunity.
The initiation of adaptive immune responses takes place in lymphoid organs, including peripheral lymph nodes (PLN).
Inside PLN, T cells become activated through the molecular interactions of the T cell receptor with cognate peptide-MHC (pMHC) molecules and costimulatory molecules on dendritic cells (DC). TCR-mediated signals lead to the activation of the phosp…
UNIVERSIDADE FEDERAL DE MINAS GERAIS
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