CORDIS Project
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This project develops a novel approach to study tumor evolution within the tumor microenvironment. By analyzing single-cell data, it aims to uncover the interactions and characteristics of tumor sub-clones that contribute to cancer progression.
The tumor microenvironment (TME) is a dynamic ecosystem wherein tumor cells, immune cells and stromal cells interact and evolve.
One of the primary characteristics of cancer progression is the diversification, selection and expansion of tumor sub-clones in manner that largely depends on the TME, e.g., through immune responses or metabolic crosstalk.
Advances in single-cell and spatial genomics provide exciting opportunities for studying how tumors evolve in their tissue context, by lending an in…
WEIZMANN INSTITUTE OF SCIENCE
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