CORDIS Project
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This project focuses on engineering proteins in the nematode worm C. elegans to study neuronal circuits. By incorporating unnatural amino acids into proteins, it aims to develop tools for controlling neuron activity and understanding behavior.
We pioneered technologies that allow the site-specific introduction of chemically synthesized unnatural amino acids (UAA) into a chosen protein within the context of a multicellular organism - the nematode worm C. elegans.
The foundational technology for this advance is genetic code expansion.In its most simple form, genetic code expansion to incorporate UAA into proteins requires an orthogonal aminoacyl-tRNA synthetase/tRNACUA pair to be introduced into the host organism.
The orthogonal aminoac…
THE UNIVERSITY OF EDINBURGH
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