CORDIS Project
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This project investigates how bacteria manipulate the host ubiquitin system during infections. By analyzing changes in ubiquitin and phosphoprotein profiles, it aims to identify new pathways for therapeutic intervention against bacterial pathogens.
Ubiquitination represents one of the most versatile post-translational modifications in eukaryotes and is involved in regulation of numerous cellular processes.
Despite prokaryotes lacking this system, facultative intracellular bacteria like Salmonella, Shigella and Legionella have evolved multiple strategies to manipulate the host ubiquitin (Ub) system to their own benefit.
This proposal is focussed on gaining a fundamental understanding of the Ub system in the course of bacterial infections. W…
JOHANN WOLFGANG GOETHE-UNIVERSITAET FRANKFURT AM MAIN
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