CORDIS Project
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This project investigates the role of the ubiquitin system in regulating RAS signaling, which is crucial in many diseases. By understanding how RAS activity is controlled through ubiquitylation, the research aims to identify new therapeutic targets for RAS-driven conditions.
The RAS pathway is the most frequently activated signaling node in human disease.
Despite intensive efforts, effective therapeutic strategies for RAS-driven disease remain daunting.
Elucidation of the mechanisms of RAS activation promises to lead toward novel therapeutic approaches to inhibit RAS activity, and may permit identification of patients who might benefit from RAS pathway inhibitors.
Our preliminary studies show that reversible ubiquitylation controls RAS activity by altering its inter…
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