CORDIS Project
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This project investigates the regulation of the NLRP3 inflammasome, which plays a key role in innate immunity and inflammation. It aims to identify the molecular mechanisms controlling NLRP3 activation and its implications for diseases like atherosclerosis and Alzheimer's through biochemical and cellular studies.
The innate immunity constitutes an efficient barrier by rapidly detecting pathogens and tissue damages through pattern recognition receptors including NLRP3.
On the other hand, inappropriate NLRP3 activation causes deleterious inflammation and contributes to various conditions including atherosclerosis, diabetes, gout and Alzheimer's diseases.
Therefore NLRP3 requires tight regulation that remains poorly characterized.
Activated NLRP3 assembles a multimeric inflammasome complex serving as activa…
INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE
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