CORDIS Project
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This project investigates how the processes of ubiquitination and sumoylation influence DNA repair and maintain genomic integrity. It focuses on the role of SUMO-targeted Ubiquitin ligases in regulating these pathways and their impact on nuclear organization during DNA repair, utilizing yeast genetics and advanced imag…
The maintenance of genomic integrity is a crucial biological process.
Among the main factors influencing genome stability are DNA repair mechanisms, which are highly conserved among eukaryotes.
There is a complex interplay and crosstalk among the different regulatory mechanisms that control DNA repair pathways.
These mechanisms often exploit post-translational modifications such as ubiquitination and sumoylation.
The recent discovery of the evolutionarily conserved family of SUMO-targeted Ubiqui…
Novartis Forschungsstiftung
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