CORDIS Project
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This project aims to understand how post-translational modifications of proteins, particularly ubiquitin and ubiquitin-like modifications, regulate cellular processes related to cancer. It combines advanced proteomic, genomic, and imaging technologies to analyze these modifications and their implications for disease.
Post-translational modifications (PTMs) of proteins are a major tool that the cell uses to monitor events and initiate appropriate responses.
While a protein is defined by its backbone of amino acid sequence, its function is often determined by PTMs, which specify stability, activity, or cellular localization.
Among PTMs, ubiquitin and ubiquitin-like (Ubl) modifications were shown to regulate a variety of fundamental cellular processes such as cell division and differentiation.
Aberrations in th…
WEIZMANN INSTITUTE OF SCIENCE
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