CORDIS Project
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The project focuses on understanding the complex regulatory system of ubiquitin modifications in cells, known as the Ub code. It aims to develop innovative tools for studying these modifications and their impact on cellular processes, with potential applications in identifying new drug targets for diseases like cancer…
Cells respond to external and internal stimuli by dynamically altering the functional status of existing proteins via post-translational modifications (PTMs).
One of the most common and versatile PTMs in eukaryotic cells is represented by the covalent attachment of the 76-amino acid protein ubiquitin (Ub) to substrate proteins (ubiquitylation).
Substrate modifications range from a single Ub moiety being attached to a protein of interest to complex polymeric Ub chains that can also contain Ub-lik…
EIDGENOESSISCHE TECHNISCHE HOCHSCHULE ZUERICH
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