CORDIS Project
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Using the nematode Caenorhabditis elegans, this project investigates age-related dysfunction in protein quality control mechanisms, particularly the Unfolded Protein Response. It aims to identify changes in this pathway that contribute to age-related disorders.
What defines the functional specialization of a cell is its unique proteome.
Proteins need to be translated and properly folded to ensure their biological function.
Several protein quality control pathways have arisen during evolution, some of them specialized in monitoring protein folding in specific organelles .
As a result of ageing, animals lose their ability to protect their proteome, leading to the accumulation of protein aggregates and the onset of age-related disorders.
The Unfolded Prot…
UNITED KINGDOM RESEARCH AND INNOVATION
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