CORDIS Project
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This project investigates how transcriptional repressors regulate gene expression, which is crucial for development and disease. It employs a combination of genome-wide experiments and bioinformatics to understand the mechanisms behind gene silencing.
Animal development and homeostasis critically depend on the accurate regulation of gene expression, which includes the silencing of genes that should not be active.
Silencing or repression of transcription is mediated by a specific class of transcription factors termed repressors that, typically via the recruitment of co-repressors, can dominantly suppress transcription, even in the presence of activating cues.
While the importance of such “active repression” is emphasized by severe developmenta…
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