CORDIS Project
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This project aims to develop nanobodies that can erase harmful inflammatory memories in hematopoietic stem cells, potentially preventing age-related immune dysfunction. The goal is to improve health outcomes by addressing chronic inflammation in the blood system.
With a growing ageing population, there is an imminent demand to develop new therapeutic strategies to ameliorate disorders of the hematopoietic system.
Our innate immune system can remember its previous encounters with inflammatory triggers.
Epigenetic memories of previous inflammatory experiences throughout an individual's lifetime are imprinted in hematopoietic stem cells (HSCs), a small pool of bone marrow progenitors that give rise to all our blood cells.
Inflammation harms HSCs causing the…
UNIVERSITATSKLINIKUM BONN
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