CORDIS Project
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This project investigates the neural mechanisms underlying chronic pain, focusing on specific neuronal ensembles in the neocortex. It aims to understand how these ensembles contribute to pain perception and the potential for reversing pain-related plasticity.
Chronic pain remains a fundamental unsolved puzzle in biology and an unmet global challenge in clinical practice.
Progress is limited by major gaps in knowledge on neural substrates, owing to overwhelming redundancy of implicated regions and pathways with several pain-unrelated sensory, cognitive and emotional functions as well as lack of understanding on the origins of plasticity and cellular substrates for diverse psychosocial and environmental influences on pain.
Here we propose that neocorti…
UNIVERSITATSKLINIKUM HEIDELBERG
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