CORDIS Project
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This project investigates the mechanisms that allow the BCL2 oncogene and other Tail Anchored proteins to be inserted into cellular membranes in mammals. By understanding this process, the research aims to enhance knowledge of BCL2 functions and its role in preventing cell death.
Activation of the BCL2 oncogene underlies a wide variety of malignant transformations. BCL2 must be present on the membranes of both the mitochondria and the endoplasmic reticulum (ER) to carry out its role in protecting cells from cell death (apoptosis).
To enable its anchoring to intra cellular membranes, BCL2 has a C-terminal hydrophobic tail in a unique topology shared by members of a large family of Tail Anchored (TA) proteins.
In mammals hundreds of such TA proteins exist that serve divers…
WEIZMANN INSTITUTE OF SCIENCE
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