CORDIS Project
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This project investigates the role of RNA interference as an antiviral mechanism in mammals, specifically in mice. It aims to identify the cell types involved, understand the underlying processes, and assess the significance of RNA interference compared to traditional immune responses.
Organisms such as plants, worms or insects rely on RNA interference (RNAi) to mount an antiviral immune response.
On the other hand, it is widely believed that the type I interferon (IFN-I) pathway replaced antiviral RNAi as a primary line of defence against viral infections in chordates.
However, recent work from multiple teams, including the host laboratory, has described a possible antiviral role for RNAi in cultured mammalian cells and in mice during infection with different RNA viruses.
The…
THE FRANCIS CRICK INSTITUTE LIMITED
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