CORDIS Project
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This project investigates the mechanisms behind migraine attacks using transgenic mouse models. It focuses on understanding changes in brain activity and sensory processing that contribute to cortical spreading depression, a key trigger for migraine pain, with the aim of improving treatment strategies.
Migraine is a disabling brain disorder with major consequences to patients and society.
Diverse genetic and physiological factors predispose for attacks, stressing the need for a multidisciplinary approach.
In the host team at the LUMC, the Netherlands, migraine research led to identification of the first migraine genes and generation of transgenic mice harboring mutations that cause hemiplegic migraine in patients.
An important focus of research at the host is on cortical spreading depression (…
Leiden University Medical Center
ACADEMISCH ZIEKENHUIS LEIDEN
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