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The project UNDERPIN investigates how nucleotide variants in untranslated regions of RNA influence the aggregation of RNA binding proteins, which is linked to neurodegenerative diseases. By exploring RNA-protein interactions, it aims to uncover the mechanisms behind protein aggregation and its implications for cell tox…
Aggregation of RNA binding proteins (RBPs) is a pathological hallmark of neurodegenerative pathologies such as Amyotrophic Lateral Sclerosis.
The mechanism leading to RBP aggregation relies on the ability of these proteins to transition into membrane-less compartments such as the stress granules (SG) whose formation is normally regulated in physiological conditions.
Yet, as RBPs are intrinsically prone to coalesce in large assemblies, their accumulation, when unregulated, can lead to cell toxici…
FONDAZIONE ISTITUTO ITALIANO DI TECNOLOGIA
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