CORDIS Project
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The project investigates how growth-induced pressure affects cell proliferation in three-dimensional environments, focusing on the role of macromolecular crowding in various organisms, including cancer cells. By using microfluidic devices, it aims to uncover the signaling pathways that enable cells to cope with physica…
Growth-induced pressure necessarily emerges when a cell population, whichever the organism, proliferates in a 3D spatially-limited environment.
Growth-induced pressure imposes physical constraints on cell physiology. A reduction of growth and division is observed in evolutionarily distant organisms such as bacteria, fungi, plants, or mammals.
However, some cells are more capable of coping with these physical limitations and proliferate than others.
This is in particular the case of cancer cells,…
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS
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