CORDIS Project
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This project investigates the assembly and function of the actomyosin contractile ring during cell division in fission yeast. By employing advanced imaging and synthetic biology techniques, it aims to visualize actin filament organization and understand the mechanisms behind cytokinesis.
The mechanism of cell division is conserved in many eukaryotes, from yeast to man. A contractile ring of filamentous actin and myosin II motors generates the force to bisect a mother cell into two daughters.
The actomyosin ring is among the most complex cellular machines, comprising over 150 proteins.
Understanding how these proteins organize themselves into a functional ring with appropriate contractile properties remains one of the great challenges in cell biology.
Efforts to generate a compre…
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