CORDIS Project
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This project aims to investigate the role of long non-coding RNA in genetic diseases caused by nucleotide repeat expansions. It focuses on identifying the molecular mechanisms involved and potential therapeutic compounds to reverse their toxic effects.
It is now increasingly clear that most of our genome is transcribed, but that only a small portion is associated with protein coding gene.
Indeed, recent analysis indicate that long non-coding RNA outnumbered by five fold the coding RNA sequences.
Despite this abundance, very little is known on the function of these long non-coding RNA.The aim of this proposal is to understand the function of pathological long non-coding RNA.
We will first focus our studies on the RNA gain-of-function diseases.…
CENTRE EUROPEEN DE RECHERCHE EN BIOLOGIE ET MEDECINE
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