CORDIS Project
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This project investigates the role of retinoid receptor RARbeta2 in oral squamous cell carcinoma development. By manipulating RARbeta2 expression in various cell stages, the project aims to understand its impact on cancer progression and identify retinoid-sensitive lesions for potential therapy.
The most common cancer in India is oral squamous cell carcinoma (OSCC), a tumour with poor survival whose incidence has also markedly increased in the UK over the past 30 years.
There has been much interest in chemoprevention of OSCC, but large clinical trials of agents such as Vitamin A analogues (retinoids) have proved disappointing.
One reason is that the function of retinoids in precancerous/cancerous oral tissues is poorly understood and this is a hindrance to individualisation of therapy…
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