CORDIS Project
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This project investigates the roles of BRCA1 and BRCA2 proteins in DNA repair and replication fork management, focusing on their interactions with co-factors and post-translational modifications. By employing biochemical techniques, the research aims to clarify how these proteins contribute to genome stability and thei…
BRCA1, BRCA2 and associated factors are frequently mutated in familial and sporadic cancers of the breast and ovary.
The BRCA proteins have canonical functions together with the RAD51 recombinase in DNA double-strand break repair by homologous recombination.
More recently, it was discovered that the same proteins have separate, recombination-independent roles in the metabolism of challenged replication forks.
It is currently debated whether defects in the canonical and/or non-canonical functions…
FONDAZIONE PER L'ISTITUTO DI RICERCA IN BIOMEDICINA
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