CORDIS Project
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This project investigates how lentiviruses, such as HIV-1, infect non-dividing cells by studying the role of nuclear envelope proteins in the viral life cycle. It aims to uncover the mechanisms that facilitate viral entry and replication within these cells.
One of the most striking characteristics of lentiviruses and one that distinguishes them from onco-retroviruses is their ability to infect nondividing cells.
As a result, primate lentiviruses such as HIV-1 can establish a productive infection in terminally differentiated cells such as macrophages and microglia in the brain or in memory T-cells that are not cycling.
The prevailing view is that those viruses are indifferent to the cell cycle status of the target cells and can infect dividing and n…
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS
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