CORDIS Project
Funding breakdown and partner intelligence are Premium
Sign in and upgrade to Premium for EU contribution totals, consortium analytics, OpenAlex research context, and AI summaries. · 0 consortium intelligence fields visible of 1
Start free • Cancel anytime • 14-day refund guarantee
This project investigates the role of mammalian sialidases, particularly Neu4 and Neu1, in the degradation of glycolipids. Using mouse models, it aims to clarify their contributions to metabolic pathways related to diseases like Tay-Sachs, potentially leading to new therapeutic strategies.
Sialidases are widely distributed in nature, from microorganisms to mammals.
Mammalian sialidases differ in their tissue distribution, subcellular localization, substrate specificity and pH optimum.
To date, several mammalian sialidases have been cloned; a lysosomal form (Neu1), a cytosolic form (Neu2), a plasma membrane-associated form (Neu3) and a lysosomal/mitochondrial form (Neu4).
Defining the functional impact of sialidases on complex physiological and cellular processes should uncover the…
Partner organizations (coordinator is shown above), with normalized type and CORDIS activity type. Guests see up to 4 partners.
Similar projects, consortium collaboration history, frequent partners, and OpenAlex research context.
Guests see up to 5 EuroSciVoc fields.
Guests see up to 5 topics.
