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The UnFearHD project investigates the relationship between protein aggregation and cellular stress responses in Huntington's disease. By studying the early stages of protein aggregation, the project aims to uncover mechanisms that impair protective cellular responses, potentially offering insights into therapeutic stra…
A common characteristic in many neurodegenerative diseases (NDs) is the presence of disordered proteins that form toxic aggregates.
In Huntington’s disease (HD), expanded polyQ tracts on Huntingtin (Htt) lead to the formation of aggregates, which affects many cellular functions, eventually resulting in cell death.
Heat Shock Response (HSR) is a protective mechanism that facilitates (among other functions) the clearance of protein aggregates.
Paradoxically, HSR becomes impaired in HD.
The fact th…
FOUNDATION FOR RESEARCH AND TECHNOLOGYHELLAS
IDRYMA TECHNOLOGIAS KAI EREVNAS
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