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UNFOLD explores the mechanisms behind the folding of the cerebral cortex, which is crucial for cognitive function. By integrating various scientific disciplines, the project aims to uncover how mechanical and molecular processes contribute to brain development and the implications for cognitive disabilities.
Mammals with large brains and higher cognitive functions have a richly folded cerebral cortex.
Folding abnormalities are linked to various cognitive disabilities.
Despite its relevance in clinical diagnostics, the causes and consequences of cortex folding remain poorly understood.
While cortex folding was long assumed to result from a limited skull volume, it is a developmental process intrinsic to the cortex.
We hypothesize that cortex folding emerges from a dynamic interplay between mechanical…
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