CORDIS Project
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This project investigates the mechanisms of alternative splicing in mRNA, which affects gene regulation and contributes to diseases like cancer and neurodegeneration. By combining various scientific approaches, it aims to identify how splicing can be modulated with small molecules, paving the way for new therapeutic st…
Alternative splicing (AS) of mRNA precursors plays important roles in tissue-specific gene regulation and biological regulatory mechanisms, as it can radically alter protein expression, cell phenotypes and physiological responses.
Altered splicing also contributes to disease mechanisms, ranging from neurodegeneration to cancer.
Drugs modulating AS have recently provided the first therapy for Spinal Muscular Atrophy, a common genetic disorder, illustrating the huge potential for treating many oth…
FUNDACIO CENTRE DE REGULACIO GENOMICA
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United Kingdom, Dundee
Type: University / higher education
Activity type: Higher or Secondary Education Establishments
SME: No
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