CORDIS Project
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The UnlockIT project focuses on understanding the interactions between cancer cells and immune cells in the tumor microenvironment to develop effective combination therapies. By utilizing advanced modeling techniques, it aims to identify mechanisms that enhance immune responses and improve treatment outcomes for cancer…
Immuno- and targeted therapies have revolutionized the treatment of cancer patients, and more innovative therapeutics, such as KRAS inhibitors (KRASi), are entering the clinic.
However, their use as monotherapies fails to achieve durable tumor control in most patients, and the development of combination therapies remains challenging without an understanding of the complex and dynamic biology that unfolds upon therapeutic challenge in the tumor microenvironment (TME).
Most of our knowledge on com…
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