CORDIS Project
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This project investigates the role of the protein phosphatase PP2A in regulating the enzyme ADAM17, which is crucial for cancer metastasis. By manipulating ADAM17 in colon cancer cells, the research aims to uncover new therapeutic strategies for treating EGFR-driven cancers.
Around 90% of all cancer-related deaths are due to metastasis.
Understanding the process of cancer metastasis is therefore of urgent need to develop new treatments.
Aberrant expression of the epidermal growth factor receptor (EGFR), or increased availability of its ligands promote tumour survival and metastasis in multiple cancers.
As a result, several anti-EGFR therapeutics are in clinical use, but almost all patients will develop resistance against the treatment.
Another strategy to treat EGFR…
KOBENHAVNS UNIVERSITET
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