CORDIS Project
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This project investigates the unconventional secretion of proteins in eukaryotic cells, particularly focusing on the cytoplasmic fatty acid-binding protein AP2. The research aims to identify new proteins and mechanisms involved in this secretory pathway, which has implications for understanding human metabolic diseases…
Most of the secreted proteins transit into and through the endoplasmic reticulum (ER) and the Golgi apparatus.
However, eukaryotic cells secrete a class of proteins, which do not enter the ER.
Very little is known about this “unconventional secretory pathway”.
The last protein identified to be secreted by this pathway is AP2, a cytoplasmic fatty acid-binding protein, which is secreted unconventionally by adipocytes to control glucose liver metabolism.
It was reported that the unconventional secr…
FUNDACIO CENTRE DE REGULACIO GENOMICA
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