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The project UNRAVEL focuses on understanding the unique properties of extracellular vesicles (EVs) to enhance RNA delivery systems. By identifying and characterizing EV subpopulations, the project aims to develop synthetic RNA delivery systems inspired by EVs, improving the efficiency of RNA therapeutics for various di…
The growing number of classes of RNA therapeutics, including siRNA, mRNA and RNA components of the CRISPR/Cas9 machinery, hold the promise of providing new treatment possibilities for almost any disease.
However, these interventions require delivery of therapeutic RNA to their final intracellular targets in diseased cells, and delivery efficiency by current RNA nanocarriers is unsatisfactory.
Endogenous nanoparticles called extracellular vesicles (EVs) have emerged as promising novel RNA deliver…
UNIVERSITAIR MEDISCH CENTRUM UTRECHT
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