CORDIS Project
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This project investigates the molecular mechanisms of nonsense-mediated mRNA decay (NMD), focusing on the protein UPF3B's role in recognizing faulty mRNAs. By employing advanced techniques, it aims to elucidate how UPF3B interacts with other components to regulate mRNA decay, which is crucial for understanding various…
In eukaryotes, gene expression is highly regulated involving multistep pathways in which mRNA plays a crucial role.
Cells have evolved surveillance mechanisms able to detect and degrade defective transcripts.
Nonsense-mediated mRNA decay (NMD) is a mRNA surveillance mechanism which detects faulty mRNAs with premature termination codons (PTCs) and targets these transcripts to decay.
By modulating the expression of physiological mRNAs, NMD acts as a post-transcriptional regulator controlling impor…
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