CORDIS Project
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This project investigates the regulatory mechanisms of the ubiquitin-proteasome system in controlling cellular metabolites. By exploring the interactions between ubiquitination enzymes and metabolic signals, it aims to uncover how these processes maintain cellular homeostasis.
Cellular metabolites are essential components of life processes, and their import, biosynthesis, and enzymatic conversion are regulated by a wealth of pathways.
The ubiquitin-proteasome system (UPS) plays a major role in ensuring that key metabolic regulators are maintained at proper levels, to control concentrations of ions, carbohydrates, amino acids, cofactors, and lipids.
In particular, the activities and localization of critical ubiquitination enzymes (E3 ligases) and the proteasome must be…
MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV
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