CORDIS Project
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This project explores the molecular mechanisms behind the stability of repetitive DNA sequences during sexual reproduction. Using yeast as a model, it aims to understand how certain systems protect these sequences from DNA breaks, which can lead to genetic disorders.
The objective of this proposal is to define the molecular basis behind the origin and protection of unstable repetitive DNA sequences during sexual reproduction.
Eukaryotic genomes contain large amounts of repetitive elements that serve vital roles in cellular physiology.
However, repetitive elements are intrinsically unstable, which is caused by a high likelihood for incorrect repair when DNA breaks form within repetitive elements.
During sexual reproduction, numerous DNA breaks are actively in…
MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV
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